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利用干细胞可望治疗秃头

[日期:2012-08-30] 来源:網絡轉載  作者:佚名 [字体: ]

5月16日在英国的‘自然’期刊上,刊登一则关于最新治疗秃头的研究,
这篇研究的主题是‘利用自己的皮肤细胞,就可以唤醒毛囊再生新发’,
以下节录了一些媒体报导与刊登在‘自然’期刊上的原文,提供给大家参考。

虽然从研究到真正成为一种安全的疗法,是需要一段时间的,但还是期盼研究的脚步能够快一些的~^_^




秃头福音! 干细胞疗法3个月生新发

ETTODAY 许瑜菁/编译  2007/05/17 

秃头不是病,但对于许多男性来说,秃头还真是要人命。不过现在有一个好消息,英国【自然】期刊最近刊登一篇研究报告,指出可以利用干细胞来恢复毛发的生长,而且过程只要3个月,就能长出自然的头发。

哥伦比亚的传说中,只要让牛伸出舌头,在人类的头上舔个几下,就能让光秃秃的头顶,长出乌溜溜的头发。不过现在可不用这么麻烦了,英国【自然】期刊最近刊出一篇报告,指出可以利用基因疗法,来帮助毛发生长。

美 国宾州大学利用老鼠进行研究,发现动物皮肤受伤后,毛囊可以自然重生,并且还会长出毛发。而科学家研发出来全新的生发之道,就是先移除直径1到2.5公分 的头皮,然后注射药物唤醒干细胞长出新的毛囊。 根据实验结果,只要3个月毛发就会自然长出,而且跟原来的毛发完全没有分别。虽然说十个秃子九个富,但不论如何,秃头总是一个尴尬的话题,让许多男性烦恼 不已。而现在这个新研发,就是希望利用干细胞生发的技术,让许多童山濯濯的男性枯木又逢春。


把基因“唤醒” 秃头可长发

人间福报 2007/05/18

【本 报综合报导】头皮上约有十万个毛囊,每个毛囊可长一根头发。科学界以往认为,毛囊是在怀孕初期的胚胎时期形成,此后一辈子都无法再生。但美国宾州大学医学 院研究人员发现,“唤醒”一个称作wnt 的基因,就可使成年老鼠重新长出毛囊。这是科学界首度发现哺乳类和两栖类,一样具有再生能力的明确证据,控制wnt的技术纯熟后,可用来治疗秃头和皮肤疤 痕。

宾州大学医学院皮肤科副教授柯萨瑞利斯,用老鼠研究皮肤愈合,意外发现wnt基因和毛囊的制造息息相关。研究人员把成年老鼠的一小部 分表皮割除后,割除区域出现类似干细胞活动的现象,包括毛囊再生。如果抑制wnt的功能,毛囊就不会再生;相反的,加强wnt作用的话,再生的毛囊增加一 倍,而新长出的皮肤和周遭皮肤看不出差异。

柯萨瑞利斯表示,我们可以利用wnt影响皮肤创伤的愈合,使得皮肤愈合后不会只留下疤痕,而是 出现正常皮肤的结构,包括毛囊和油脂腺。wnt基因技术不但可治疗雄性秃、防止皮肤伤口形成疤痕,也可用来治疗毛发过度生长的问题。他表示,顺利的话,预 计五到十年内可研发出让毛囊再生的药物。

毛囊可再生 治秃头有望
苹果日报  2007/05/18

【蔡佳慧╱综合外电报导】发际线随年龄增长而向后狂退,实在让人胆颤心惊。不过,好消息来了,美国科学家透过老鼠实验,宣布首度成功让毛囊“再生”的突破性研究成果。未来这项技术将可用来治疗秃头,甚至是解决面疱等问题。

宾州大学医学院研究人员在《自然》(Nature)期刊上发表最新研究,指称成年哺乳类动物的皮肤细胞仍可以自然“再生”出毛囊,原理是透过唤醒一系列沉睡的基因,促使干细胞集中于无毛发的皮肤区域,干细胞之后会形成毛囊细胞,使皮肤长出毛发。

此外,科学家更发现,若在皮肤上注射一种名为Wnt的蛋白质,可让毛囊数量倍增。相反地,抑制该蛋白质则将停止新毛囊生长。研究主要作者柯斯特撒利斯医师说:“我们发现透过Wnt可影响伤口愈合,不仅伤疤小还会长出正常的皮肤结构,如毛囊和油脂腺。”
这项结果给医界带来大震撼。过去医界普遍认为,成年哺乳类动物只拥有固定数量的毛囊,失去了就无法再生新的。

Published online: 16 May 2007

Skin's own cells could beat baldness -- Research on mice raises hopes for regrowing hair.

Initiating the same process that happens after wound healing could spout new hairs.

Skin may have the capacity to regenerate lost hair follicles from within, according to a new discovery that could yield better treatments for baldness or abnormal hair growth. Researchers in the United States have found that, when skin is wounded, epidermal cells can respond by assuming the properties of stem cells that generate hair follicles and growing new hair.
 

The researchers removed patches of skin from mice and studied the wounds as they healed during the ensuing weeks. As they report in this week's <i>Nature</i>1, cells that had not initially been associated with hair follicles began to express genes found in the stem cells that give rise to follicles during development. Hair growth occurred regardless of the mouse's age, the researchers report, although the new hairs did not contain pigment.

That's what happens in mice, report George Cotsarelis and his team at the University of Pennsylvania School of Medicine in Philadelphia. If the same is true of human skin, the research raises the possibility that older men with established baldness could be successfully restored to their former hirsute glory.
 

The process happened naturally after wounding. But the researchers found they could boost the effect by using mice that had been genetically engineered to produce higher levels of proteins that activate the genetic pathway underpinning the transformation to follicle stem cells. These mice responded to wounding by producing twice the density of hairs found in the coats of normal, untreated mice.

Cotsarelis and his colleagues now hope to mimic this for human skin. They envisage a treatment similar to the 'dermabrasion' used to treat skin scarred by teenage acne — a process that uses gentle damage to encourage wound healing processes — combined with a topical cream to activate the genetic pathway.

"It's all preliminary at the moment," says Cotsarelis, who has helped to set up a company, Follica, that will attempt to bring the idea to market. "If it all went perfectly then possibly in two to three years we would have a product, but that's very optimistic."

Hair today, gone tomorrow

Previously, it was generally accepted that hair follicles cannot be regrown after a person reaches adulthood, meaning that once they are lost — through skin damage or the baldness-promoting effects of some hormones — they are gone forever.

Although experts first suggested that follicle regrowth might be possible half a century ago, no one had ever proved the cells' regenerative capability.

The fact that it occurs as a result of skin damage might explain why the process has taken so long to find and verify, Cotsarelis reflects. "Most people studying skin wounding don't pay a lot of attention to hair follicles," he says. "They view wound closure as the end-point."

The discovery opens up new insights into how skin functions. The research "provides convincing evidence that the skin has remarkable powers of regeneration, not just repair," says Desmond Tobin, a cell biologist at the University of Bradford, UK.

But baldness treatments will be the inevitable focus of further research in this area.

No more toupees

Current baldness treatments include minoxidil, which expands blood vessels in the scalp; anti-androgens, which attempt to minimize the ravages of testosterone and its related hormones; and hair-follicle transplants.

Using these existing treatments is "a long and slow process", says Carol Michaelides, a consultant at the Philip

Kingsley Trichological Clinic in London. What's more, the chances of success diminish both with age and with the degree of hair thinning. "The accepted baseline is 30 hairs per square centimetre," says Michaelides. A healthy head will boast many hundreds of hairs in the same area of scalp.

Another area of research currently being pursued is the idea of transplanting follicular stem cells into the scalp from another source, although this approach is also several years from the clinic, Michaelides says. But if the scalp can be induced to create its own new follicles, it would be "a huge step forward", she adds.

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