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口服三烯生育醇对头发生长影响的临床实验(下)

[日期:2012-08-30] 来源:網絡轉載  作者:佚名 [字体: ]

Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers
补充三烯生育醇对头发生长的影响

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研究结果与讨论

三十八位有异常掉发情况或秃头的志愿受试者参加了研究,口服三烯生育醇组有21名志愿者(192女),安慰剂组(对照组)有17个志愿者(全部为男性)。该研究的人口年龄介于 1859岁。受试者年龄范围广泛,因为掉发是不受年龄之限制。年轻的成年人与老年人都会有受到掉发问题的影响。此外,掉发可能是由于营养缺乏和氧化压力所导致,从而影响广泛的年龄组。受试者掉发问题大约有2~5年的时间。

研究开始前,针对受试组成员的头发数以及头发重量加以评估。
安慰剂组受试者的毛发的平均数目基线为289.0 ± 98.3,而补充三烯生育醇组为284.8 ± 111.3。至于20股头发平均重量,安慰剂组受试者的毛发的平均数目基线为0.1002克和 ±0.0639,而补充三烯生育醇组为0.0920 ± 0.0565克。比较两组的两个参数并没有显著差异(P> 0.05)。

三十五位受试者完成了整个研究,并评价补充三烯生育醇的效果。三名受试者中止研究,一位()是三烯生育醇组,和两位安慰剂组。每个月记录与访视过程中,补充三烯生育醇的顺从性是令人满意的。两组皆无严重药物反应或有关的记录。从而表明,持续8个月服用100毫克的生育三烯酚是可以忍受的。研究方案也被认为是令人满意的,没有偏差协定的记录。

1显示了受试者在基线,第4和第8个月的头发数量变化,以及发量增加的百分比变化。显而易见的是,三烯生育醇补充组,从基线到第8个月的时间,头发数量有逐渐增加,最后平均增幅超过 34%。相比之下,安慰剂组受试者没有表现出任何明显的发量增加,约减少0.1%。杜克的事后检验表明(Tukey’s post-hoc test),补充三烯生育醇的受试者头发增加并无安慰剂效应。成对比较还表明,8个月的时间,补充三烯生育醇组和安慰剂组噢试者的头发数量有显著差异。


研究结束时,对于头发数量增加的效果评估,有一个志愿受试者例外。整体而言,8名志愿者(40.0%)显示头发增加了50%以上,1名志愿(5.0%)有25%至50%的增幅,9名受试者(45.0%)有增加10%至25%,而1名受试者(5.0% )为头发增加不到10%。只有1名受试者(5.0%)发量有些微减少。另一方面,在8个月后,在安慰剂组有8个志愿者显示有增加头发的数量,1名(6.7%),显示超过 20%的增长,其余 7名(46.7%),显示微不足道(negligible)的增加。7名受试者(46.7%)头发减少。

然而,两组的头发重量并没有显著增加。三烯生育醇补充组,平均百分比增重了5.9%的,而安慰剂组有轻微下降2.0%(见表 2)。研究结果之后,另行补充相关的研究显示,抗氧化剂可能被用来控制雄性秃掉发。

结论

总之,本试验表明,补充三烯生育醇胶囊的受试者与安慰剂组相比,头发数量有增加。
一种可能的解释,效果可能是由于强大的抗氧化活性的生育三烯醇,以帮助降低头皮的脂质过氧化和氧化压力。

参考资料

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